Laurinda A. Jaffe

Research interests:

Signal transduction during oocyte maturation and fertilization

Lab members:

Rachael Norris - Graduate student - norris@student.uchc.edu; 860 679 3476
Will Ratzan - Graduate student - wratzan@uchc.edu; 860 679 2677
Marina Freudzon - Research assistant - marina.freudzon@gmail.com
Group photo 1 - Group photo 2
Past lab members

Movies and posters:
Microinjection of an antral follicle enclosed mouse oocyte (with sound)
Biophysics Meeting 2009 poster

Recent publications

Norris, R.P., Ratzan, W.J., Freudzon, M., Mehlmann, L.M., Krall, J., Movsesian, M.A., Wang, H., Ke, H., Nikolaev, V.O., and Jaffe, L.A. (2009). Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development 136: 1869-1878. pdf - supplement.

Jaffe, L.A., Norris, R.P., Freudzon, M., Ratzan, W.J., and Mehlmann, L.M. (2009). Microinjection of follicle-enclosed mouse oocytes. Methods Mol. Biol. 518:157-173. pdf.

Norris, R.P., Freudzon, M., Mehlmann, L.M., Cowan, A.E., Simon, A.M., Paul, D.L., Lampe, P.D., and Jaffe, L.A. (2008). Luteinizing hormone causes MAPK-dependent phosphorylation and closure of Cx43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption. Development 135:3229-3238. pdf - supplement.

Norris, R.P., Freudzon, L., Freudzon, M., Hand, A.R., Mehlmann, L.M., and Jaffe, L.A. (2007). A Gs linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor Gs signaling. Develop. Biol. 310: 240-249. pdf.

Mehlmann, L.M., Kalinowski, R.R., Ross, L.F., Parlow, A.F., Hewlett, E.L., and Jaffe, L.A. (2006). Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte. Develop. Biol. 299: 345-355. pdf.

Freudzon, L., Norris, R.P., Hand, A.R., Tanaka, S., Saeki, Y., Jones, T.L.Z., Rasenick, M.M., Berlot, C.H., Mehlmann, L.M., and Jaffe, L.A. 2005. Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein. J. Cell Biol. 171: 255-265. pdf.

Jaffe, L.A., and Terasaki, M. 2004. Quantitative microinjection of oocytes, eggs and embryos. Meth. Cell Biol. 74: 219-242. pdf.

Kalinowski, R.R., Berlot, C.H., Jones, T.L.Z., Ross, L.F., Jaffe, L.A., and Mehlmann, L.M. 2004. Maintenance of meiotic prophase arrest in vertebrate oocytes by Gs protein-mediated pathway. Develop. Biol. 267: 1-13. pdf.

Mehlmann, L.M., Saeki, Y., Tanaka, S., Brennan, T.J., Evsikov, A.V., Pendola, F.L., Knowles, B.B., Eppig, J.J., and Jaffe, L.A. 2004. The Gs linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science 306: 1947-1950. pdf - supplement

Department of Cell Biology Faculty