Laurinda A. Jaffe

Research interests:

Signal transduction during oocyte maturation and fertilization

Lab members:

Rachael Norris - Graduate student - norris@student.uchc.edu; 860 679 2677
Will Ratzan - Graduate student - wratzan@uchc.edu; 860 679 2677
Marina Freudzon - Research assistant - freudzon@uchc.edu; 860 679 2737
Group photo 1 - Group photo 2
Past lab members

Images and Movies:
Microinjection of an antral follicle enclosed mouse oocyte

Current projects:
ASCB 2007 poster - Luteinizing hormone decreases the permeability of somatic cell gap junctions in the mouse ovarian follicle, prior to nuclear envelope breakdown.

Recent publications

Mehlmann, L.M., Jones, T.L.Z., and Jaffe, L.A. 2002. Meiotic arrest in the mouse follicle maintained by a Gs protein in the oocyte. Science 297: 1343-1345. pdf

Mehlmann, L.M., Saeki, Y., Tanaka, S., Brennan, T.J., Evsikov, A.V., Pendola, F.L., Knowles, B.B., Eppig, J.J., and Jaffe, L.A. 2004. The Gs linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science 306: 1947-1950. pdf - supplement

Kalinowski, R.R., Berlot, C.H., Jones, T.L.Z., Ross, L.F., Jaffe, L.A., and Mehlmann, L.M. 2004. Maintenance of meiotic prophase arrest in vertebrate oocytes by Gs protein-mediated pathway. Develop. Biol. 267: 1-13. pdf.

Jaffe, L.A., and Terasaki, M. 2004. Quantitative microinjection of oocytes, eggs and embryos. Meth. Cell Biol. 74: 219-242.

Freudzon, L., Norris, R.P., Hand, A.R., Tanaka, S., Saeki, Y., Jones, T.L.Z., Rasenick, M.M., Berlot, C.H., Mehlmann, L.M., and Jaffe, L.A. 2005. Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein. J. Cell Biol. 171: 255-265. pdf.

Mehlmann, L.M., Kalinowski, R.R., Ross, L.F., Parlow, A.F., Hewlett, E.L., and Jaffe, L.A. (2006). Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte. Develop. Biol. 299: 345-355.

Norris, R.P., Freudzon, L., Freudzon, M., Hand, A.R., Mehlmann, L.M., and Jaffe, L.A. (2007). A Gs linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor Gs signaling. Develop. Biol. 310: 240-249.

Department of Cell Biology Faculty