Ingela Jansson
Assistant Professor
Department of Cell Biology
University of Connecticut Health Center
Farmington, CT 06032
phone 860 679 2669
fax 860 679 2473
email ijansson@neuron.uchc.edu
Education
B.A., University of Stockholm
Ph.D., University of Stockholm
Research interests
Dr. Jansson has two main areas of interest. Her studies on the cytochrome P450-containing monooxygenases responsible for drug, chemical and steroid oxidation involve protein-protein interaction, and concentrate on the nature of the charge pairing between cytochromes b5 and P450, as well as the topography of the enzymes within the endoplasmic reticulum membrane. An hypothesis as to the role of cytochrome b5 in the interaction with P450 has recently been proposed, whereby cytochrome b5 serves as an electron buffer, transforming P450 into a two electron acceptor complex. This is currently being tested.
The second area of study involves identification and purification of DNA-binding proteins responsible for Cd(II)- and Zn(II)- induction of metallothionein in frog embryos during early development. Radioactive metal probes are used on Western blots for identification of these proteins. The mechanism of induction and the relationship to teratogenicity of heavy metals in Xenopus are also under investigation.
Department of Cell Biology Faculty
