Bruce A. White
Professor
Department of Cell Biology
University of Connecticut Health Center
263 Farmington Ave
Farmington, CT 06032
bwhite@nso2.uchc.edu
860 679 2811
860 679 1269 (fax)
Research Interests
Role of the scaffolding/signalling protein, ezrin, in the regulation of pituitary lactotrope function by estrogen. The role of ezrin, and the regulation of ezrin activation and distribution in the oocyte during maturation and ovulation. Estrogenic regulation of low-density lipoprotein receptor in breast cancer.
New Research Opportunities
Dr. White (in collaboration with Dr. Henry Furneaux) was recently (i.e., September 2005) funded by NIH to study the regulation of microRNA expression by estrogen in human breast cancer and liver cell lines, and the possible roles of hormonally-regulated microRNAs in the control of cellular cholesterol homeostasis. This represents a "ground floor" project that is ideal for a student rotation or thesis project.
Recent
cover of Molecular Endocrinology - Full size
Recent Publications
Peluso, J., Fernandez, G., Pappalardo, A., and White, B.A. (2001) Biol. Reprod. 65, 94-101. Characterization of a putative membrane receptor for progesterone that is involved in preventing granulosa cell apoptosis.
Smith, P., Heinrich, C.A., Pappas, S., Peluso, J.J., Cowan, A.E., and White, B.A. (2002) Endocrine 17, 219-228. Reciprocal regulation by estradiol 17-b of ezrin and cadherin-catenin complexes in a pituitary cell line.
Peluso, J., Bremner, T., Fernandez, G., Pappalardo, A., and White, B.A. (2003) Biol. Reprod. 68, 122-128. Expression pattern and role of a 60-kilodalton progesterone binding protein in regulating granulosa cell apoptosis: involvement of the mitogen-activated protein kinase cascade
White, B.A. 2003 In: Encyclopedia of the Human Genome Project (Cooper, D., Editor-in-Chief), Nature Publishing Group, London. PCR: design and optimisation of reactions
Smith, P.M., Cowan, A., Milgram, S., and White, B.A. (2003) Endocrine 22: 119-126. Tissue-specific regulation by estrogen of ezrin and 50 kDal ezrin-binding protein (EBP50).
Smith, P.J., Cowan, A.E., and White, B.A. (2004) Endocrinology 145: 3075-3083. The LDL receptor is regulated by estrogen and forms a functional complex with the estrogen regulated protein ezrin in pituitary GH3 somatolactotropes.
Graduate Students:
Dr. Daniel Lyman, (Ph.D., 1988)
Dr. Gregory Preston (Ph.D., 1990)
Dr. John Lynch (MD/Ph.D., Ph.D., 1992)
Dr. William Billis (Ph.D., 1995)
Ms. Puja Agarwal (M.Sc., 1995)
Dr. Melissa Lail-Trecker (Ph.D., 1996)
Dr. Meimei Hu (Ph.D., 1997)
Dr. Amanda Heinrich (Ph.D., 1999)
Mr. Perry Smith (MD/Ph.D.; successfully defended Ph.D. in 2004, currently 4th year Medical Student)
