Skip to Search
Skip to Navigation
Skip to Content

UConn Health Department of Cell Biology

Kimberly Dodge-Kafka

Kimberly L. Dodge-KafkaAssociate Professor
Department of Cell Biology

Contact

Phone: 860-679-2452
Email: dodge@uchc.edu
Office: ARB G029

UConn Health
263 Farmington Avenue
Farmington, CT 06030


Research Interests

My research focuses on defining the intracellular communication networks that promote specificity in signal transduction.  In particular, we work on A-kinase-anchoring proteins (AKAPs) that target the camp-dependent protein kinase, as well as other signaling enzymes, into discrete signaling complexes in order to regulate the phosphorylation of target proteins.  In particular, we are concentrating on AKAP complexes in the heart, and how they regulate cardiac physiology.


 Selected Publications

Analysis of AKAP7γ Dimerization. Singh A, Rigatti M, Le AV, Carlson CR, Moraru II, Dodge-Kafka KL. J Signal Transduct. 2015;2015:371626. doi: 10.1155/2015/371626. Epub 2015 Aug 31. PMID: 26417456.

Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Rigatti M, Le AV, Gerber C, Moraru II, Dodge-Kafka KL. Cell Signal. 2015 Sep;27(9):1807-15. doi: 10.1016/j.cellsig.2015.05.016. Epub 2015 May 28.

mAKAP-a master scaffold for cardiac remodeling. Passariello CL, Li J, Dodge-Kafka K, Kapiloff MS. J Cardiovasc Pharmacol. 2015 Mar;65(3):218-25. doi: 10.1097/FJC.0000000000000206. PMID: 25551320.

Architectural and functional roles of A kinase-anchoring proteins in cAMP microdomains. Michael S. Kapiloff, Marc Rigatti and Kimberly L Dodge-Kafka. J Gen Physiol. 2014 Jan;143(1):9-15. doi: 10.1085/jgp.201311020 .

The Scaffold Protein mAKAPβ Orchestrates Cardiac Myocyte Hypertrophic Signaling Required for the Development of Heart Failure. Michael D. Kritzer, Jinliang Li, Catherine L. Passariello, Marjorie Gayanilo, Hrishikesh Thakur, Joseph Dayan, Kimberly Dodge-Kafka, and Michael S. Kapiloff.  Circ Heart Fail. 2014 May 8. [Epub ahead of print]

Scaffold State-Switching Amplifies, Accelerates and Insulates PKC Signaling. Greenwald EC, Redden JM, Dodge-Kafka KL, Saucerman JJ. J Biol Chem. 2013 Dec 3. [Epub ahead of print]

Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes. Li J, Vargas MA, Kapiloff MS, Dodge-Kafka KL. Exp Cell Res. 2013 Feb 15;319(4):447-54. doi: 10.1016/j.yexcr.2012.12.016. Epub 2012 Dec 21.

Anchored p90 Ribosomal S6 Kinase 3 is required for cardiac myocyte hypertrophy. Li J, Kritzer MD, Carlisle Michel JJ, Le A, Thakur H, Gayanillo M, Passariello CL, Negro A, Daniel JB, Oskouel B, Sanders M, Hare JM, Hanauer A, Dodge-Kafka KL, Kapiloff MS. Circ Res. 2013 Jan 4;112(1):128-39. doi: 10.1161/CIRCRESAHA.112.276162. Epub 2012 Sep 20.

LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation. Mian I, Pierre-Louis WS, Dole N, Gilberti R, Dodge-Kafka KL, Tirnauer J. PloS One 2012;7(2):e31583

 Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation.  Vargas MAX, Tirnauer JS, Glidden N, Kapiloff MS,  Dodge-Kafka KL. Cell Signal 2012 Aug;24(8):1496-503.

Spatiotemporal Regulation of PKC via Interactions with AKAP7 Isoforms.  Redden JM, Le AV, Singh A, Federickiewicz K, Smith S, Dodge-Kafka KL. Biochem J. 2012 Sep 1;446(2):301-9. doi: 10.1042/BJ20120366

AKAPs: The architectural underpinnings of local cAMP signaling.  Kritzer MD, Li J, Dodge-Kafka K, Kapiloff MS. J Mol Cell Cardiol.  2012 Feb;52(2):351-8. doi: 10.1016/j.yjmcc.2011.05.002. Epub 2011 May 11.

AKAP Phosphatase Complexes in the Heart.  Redden JM, Dodge-Kafka KL.  J Cardiovasc Pharmacol. 2011 Oct;58(4):354-62.

Identification of AKAP79 as a protein phosphatase 1 catalytic binding protein.  Le AV, Tavalin SJ, Dodge-Kafka KL.  Biochemistry. 2011 Jun 14;50(23):5279-91. Epub 2011 May 16.

The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity.  Singh A, Redden JM, Kapiloff MS, Dodge-Kafka KL.  Mol Pharmacol. 2011 Mar;79(3):533-40. Epub 2010 Dec 13.

Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. Habrukowich C, Han DK, Le A, Rezaul K, Pan W, Ghosh M, Li Z, Dodge-Kafka K, Jiang X, Bittman R, Hla T. J Biol Chem. 2010 Aug 27;285(35):26825-31. Epub 2010 Jun 17.

cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.  Dodge-Kafka KL, Bauman A, Mayer N, Henson E, Heredia L, Ahn J, McAvoy T, Nairn AC, Kapiloff MS.  J Biol Chem. 2010 Apr 9;285(15):11078-86. Epub 2010 Jan 27.

The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin.  Li J, Negro A, Lopez J, Bauman AL, Henson E, Dodge-Kafka K, Kapiloff MS. J Mol Cell Cardiol. 2010 Feb;48(2):387-94. Epub 2009 Oct 31.

A-kinase anchoring proteins as the basis for cAMP signaling.  Dodge-Kafka KL, Bauman A, Kapiloff MS.  Handb Exp Pharmacol 2008;(186):3-14

Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha.  Michel JJ, Townley IK, Dodge-Kafka KL, Zhang F, Kapiloff MS, Scott JD. Mol Cell. 2005 Dec 9;20(5):661-72.

The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling.  Pare GC, Bauman AL, McHenry M, Michel JJ, Dodge-Kafka KL, Kapiloff MS. J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46.

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.  Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS, Scott JD. Nature. 2005 Sep 22;437(7058):574-8.

PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex.  Carlisle Michel JJ, Dodge KL, Wong W, Mayer NC, Langeberg LK, Scott JD. Biochem J. 2004 Aug 1;381(Pt 3):587-92.

Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360.  Dell'Acqua ML, Dodge KL, Tavalin SJ, Scott JD. J Biol Chem. 2002 Dec 13;277(50):48796-802. Epub 2002 Sep 26.

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.  Dodge KL, Khouangsathiene S, Kapiloff MS, Mouton R, Hill EV, Houslay MD, Langeberg LK, Scott JD.  EMBO J. 2001 Apr 17;20(8):1921-30