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UConn Health Department of Cell Biology

John. J. Peluso

John. J. PelusoProfessor
Department of Cell Biology

Education and Training

Ph.D., West Virginia University


Phone: 860-679-2860
Office: E6041

Cell Biology Graduate Program Page

UConn Health
263 Farmington Avenue
Farmington, CT 06030

Research Interests

Hormonal control of ovarian follicular growth and atresia; cellular and molecular mechanisms involved in apoptosis and mitosis; and characterization of a novel membrane receptor for progesterone (PGRMC1) including the elucidation of its signal transduction pathway. Studies included identification of proteins that bind PGRMC1 using proteomics, protein-protein interaction assays and genetic approaches to deplete or enhance expression. Additional studies are being conducted on PGRMC1's role in modulating ovarian function using our conditional PGRMC1 knockout mouse.


Expression and structural features of a novel membrane receptor for progesterone (PGRMC1). The panel at the left shows the different domains of PGRMC1. However, the proteins that bind PGRMC1 and are presumably involved in ligand activated signal transduction have not been identified. The panel at the right shows the expression of PGRMC1 within the immature rat ovary.

Lab Member (room E6038): 

                                      Erica Anspach Will

                                      M.D., OB/GYN
                                      Phone: 860-679-3790

Selected Publications

Will, EA, Liu, X,  Peluso, JJ. AG 205, a PGRMC1 Antagonist, Ablates Progesterone’s Ability to Block Oxidative Stress-Induced Apoptosis of Human Granulosa/Luteal Cells. Biol Reprod. 2017 Mar 23. doi: 10.1093/biolre/iox013. [Epub ahead of print . pdf

Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK. Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence. Endocrinology. Mar 1; 2017. 158:640-651. pdf

Luciano AM, Peluso JJ. PGRMC1 and the faithful progression through mitosis and meiosis. Cell Cycle. 2016 Sep;15(17):2239-40. Epub 2016 Jun 29. pdf

 McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK. Conditional ablation of progesterone receptor membrane component 1 results in subfertility in the female and development of endometrial cysts. Endocrinology. 2016 Sep;157:3309-19. pdf

Clark, NC, Friel, AM,  Pru, CA, Zhang, L, Shioda, T, Rueda, BR , Peluso, JJ,  and Pru, JK. Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors. Cancer Biol Ther. 2016 Mar 3;17(3):262-71. pdf

Friel, AM, Zhang, L, Pru, C A, Clark, NC, McCallum, ML, Blok, LJ, Shioda, T, Peluso, JJ, Rueda, BR and Pru, J. K:  Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors.  Cancer Letters   DOI 10.1016/j.canlet.2014.09.036, 2015.

Dey, S, Chamero, P, Pru, J K, Chien, M-S, Ibarra-Soria, X, Spencer, K R, Logan, D W, Matsunami, H, Peluso, J J, and Stowers, L:  Cyclic regulation of sensory perception by a female hormone alters behavior.  Cell 161: 1334-1344, 2015. pdf

Sueldo, C, Liu, X and Peluso, JJ:  Progestin and adipoQ receptor 7, Progesterone Membrane Receptor Component 1 (PGRMC1) and PGRMC2 and their role in regulating progesterone’s ability to suppress human granulosa/luteal cells from entering into the cell cycle.  Biol Reprod 93, 63-74, 2015.

Griffin,D, Liu, X, Pru,C, Pru, JK and Peluso, JJ:  Expression of Progesterone Receptor Membrane Component- 2 within the Immature Rat Ovary and its Role in Regulating Mitosis and Apoptosis of Spontaneously Immortalized Granulosa Cells  Biol Reprod 91: 36, 1-11, 2014  pdf

Peluso, JJ, Griffin,D, Liu, X, Horne, M:  Progesterone Receptor Membrane Component-1 (PGRMC1) and PGRMC-2 interact to suppress entry into the cell cycle in spontaneously immortalized granulosa cells.  Biol Reprod 91: (5) 104, 1-12, 2014 pdf

 Peluso, JJ:  Progesterone receptor membrane component 1 and its role in ovarian follicle growth.  Frontiers in Neuroscience 7 (article 99) 1-7, 2013 pdf

Luciano, AM, Franciosi, F, Lodde, V, Tessaro, I, Corbani, D, Modina, S  and Peluso, JJ:  Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of Progesterone Receptor Membrane Component-1 and Aurora Kinase-B. Biol Reprod  2013. pdf

Peluso, JJ, Yuan, A, Liu, X and Lodde, V:  Plasminogen Activator Inhibitor 1 RNA Binding Protein Interacts with Progesterone Receptor Membrane Component 1 to Regulate Progesterone's Ability to Maintain the Viability of Spontaneously Immortalized Granulosa Cells.  Biol Reprod. 2012 Dec 12. pdf

Elassar, A, Liu, X, Scranton, V, Wu, CA, and Peluso, JJ: The relationship between follicle development and progesterone receptor membrane component-1 (PGRMC1) expression in women undergoing in vitro fertilization.  Fert Steril.  97: 572-578, 2012. pdf

Peluso, JJ, DeCerbo, J, and Lodde, V: Evidence for a genomic mechanism of action for Progesterone Receptor Membrane Component-1.  Steroid 77: 1007-1012, 2012. pdf

Luciano, AM, Corbani,D, Lodde, V, Tessaro, I, Franciosi, F, Peluso, JJ, and Modina, S:  Expression of Progesterone Receptor Membrane Component-1 in bovine reproductive system during estrous cycle. Europ J Histchem Cytochem 55: 145-150, 2011. pdf

Engmann, L, Romak, J, Nulsen, J, Benadiva, C, and Peluso, JJ:  The in-vitro viability and secretory capacity of human luteinized granulosa cells after gonadotropin releasing hormone (GnRH) agonist trigger of oocyte maturation.  Fert. Steril 96: 198-202, 2011 (doi:10.1016/j.fertnstert.2011.04.071). pdf

Lodde, V, and Peluso, JJ: A Novel Role for Progesterone and Progesterone Receptor Membrane Component 1 in Regulating Spindle Microtubule Stability During Rat and Human Ovarian Cell Mitosis.  Biol Reprod, 84:715-722, 2011. (doi:10.1095/biolreprod.110.0883852010). pdf

Peluso, J.J. Progesterone Signaling Mediated Through Progesterone Receptor Membrane Component-1 in Ovarian Cells with Special Emphasis on Ovarian Cancer. Steroids 76: 903-909, 2011. pdf

Wendler, A., Keller, D., Alberecht, C., Peluso, J.J., and Wehling, M. Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component-1 expression in ovarian cancer cells. Oncology Reports 25: 273-279, 2010. pdf

Luciano, A.M., Lodde, V., Franciosi, F., Cecillani, F., and Peluso, J.J. Progesterone Receptor Membrane Component-1 Expression and Putative Function in Bovine Oocyte Maturation, Fertilization and Early Embryonic Development. Reproduction 140: 663-672, 2010. pdf

Peluso, J.J., Liu, X., Gawkowska, A., Lodde, V., and Wu, C.A. Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression. Mol Cell Endocr 320: 153-161, 2010. pdf

Wu, C.A., Peluso, J.J., Zhu, L., Lingenheld, E.G., Walker, S.T., and Puddington, L. Bronchial Epithelial Cells Produce IL-5: Implications for Local Immune Responses in the Airways Cellular Immunology 264: 32-41, 2010. pdf