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UConn Health Department of Cell Biology

Annabelle Rodriguez-Oquendo, MD

Linda and David Roth Chair for Cardiovascular Research
Center for Vascular BiologyJoel Pachter and Department of Cell Biology


Phone: (860) 679-2463
Office: E5050

UConn Health
263 Farmington Avenue 
Farmington, CT 06030


Research Interests

The Rodriguez-Oquendo lab is studying the genetic link between healthy HDL cholesterol, heart disease, and infertility in women. This work suggests that variations within the SCARB1 gene, connected to HDL levels, are associated with heart disease risk as well as hormonal and fertility problems in women. The goal of the research discoveries is the development of methods to diagnose and, ultimately, treat heart disease and improve a woman’s ability to conceive.


Scientist of the Year, 2013, Great Minds in STEM.

Selected Publications

 Diana Golden, Antonina Kolmakova,Sunitha Sura,Anthony T. Vella, Ani Manichaikul, Xin-Qun Wang, Suzette J. Bielinski,Kent D. Taylor, Yii-Der Ida Chen, Stephen S. Rich, and Annabelle Rodriguez. Lymphocyte activation gene 3 and coronary artery disease. JCI Insight. 2016;1(17):e88628. doi:10.1172/jci.insight.88628. pdf

Ménoret A, Crocker SJ, Rodriguez A, Rathinam VA, Clark RB, Vella AT. Transition from identity to bioactivity-guided proteomics for biomarker discovery with focus on the PF2D platform. Proteomics Clin Appl. 2016 Jan;10(1):8-24. doi: 10.1002/prca.201500029. Epub 2015 Sep 16. Review. pdf

Cameron SJ, Morrell CN, Bao C, Swaim AF, Rodriguez A, Lowenstein CJ. A Novel Anti-Inflammatory Effect for High Density Lipoprotein.  PLoS One. 2015 Dec 17;10(12):e0144372. doi: 10.1371/journal.pone.0144372. eCollection 2015. pdf

Everett BM, Brooks MM, Vlachos HE, Chaitman BR, Frye RL, Bhatt DL; BARI 2D Study Group. Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes. N Engl J Med. 2015 Aug 13;373(7):610-20. doi: 10.1056/NEJMoa1415921. pdf

Manichaikul A, Wang XQ, Musani SK, Herrington DM, Post WS, Wilson JG, Rich SS, Rodriguez A. Association of the Lipoprotein Receptor SCARB1 Common Missense Variant rs4238001 with Incident Coronary Heart Disease. PLoS One. 2015 May 20;10(5):e0125497. doi: 10.1371/journal.pone.0125497. eCollection 2015. pdf

Vickers KC, Rodriguez A. Human scavenger receptor class B type I variants, lipid traits, and cardiovascular disease.  Circ Cardiovasc Genet. 2014 Dec;7(6):735-7. doi: 10.1161/CIRCGENETICS.114.000929. No abstract available. pdf

DeAngelis AM, Roy-O'Reilly M, Rodriguez A. Genetic alterations affecting cholesterol metabolism and human fertility. Biol Reprod. 2014 Nov;91(5):117. doi: 10.1095/biolreprod.114.119883. Epub 2014 Aug 13. Review. pdf

Rodriguez A, Magee M, Ramos P, Seley JJ, Nolan A, Kulasa K, Caudell KA, Lamb A, MacIndoe J, Maynard G. Best Practices for Interdisciplinary Care Management by Hospital Glycemic Teams: Results of a Society of Hospital Medicine Survey Among 19 U.S. Hospitals.  Diabetes Spectr. 2014 Aug;27(3):197-206. doi: 10.2337/diaspect.27.3.197. pdf

Manichaikul, A., Naj, A.C., Herrington, D., Post, W., Rich, S.S., Rodriguez, A., 2012. Association of SCARB1 variants with subclinical atherosclerosis and incident cardiovascular disease: The Multi-Ethnic Study of Artherosclerosis. Arterioscl Throm Vas 32: pp. 1991-1999. pdf

Yates, M., Kolmakova, A., Zhao, Y., Rodriguez, A.  2011. Clinical impact of scavenger class B type I gene polymorphisms on human female fertility, Hum Reprod 26: pp. 1910-1916. pdf

Rodriguez, A., Canto, M.I., Makary, M.A., 2011. Endoscopic localization and tattooing of a proinsulinoma for minimally invasive resection. Pancreas 40: pp. 474-477. pdf

Zhao, Y., Garcia, J., Kolp, L., Cheadle, C., Rodriguez, A., Vlahos, N.F., 2010. The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Fertil Steril 94: pp. 2264-2271. pdf

Kolmakova, A., Wang, J., Brogan, R., Chaffin, C., Rodriguez, A. 2010. Deficiency of scavenger receptor class B type I receptor negatively affects progesterone secretion in human granulosa cells. Endocrinology 151: pp. 5519-5527. pdf

Naj, A.C., West, M., Rich, S.S., Post, W., Kao, W.H.L., Herrington, D.M., Wasserman, B., Rodriguez, A. 2010. Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: Multi-Ethnic Study of Atheroschlerosis. Circ Cardiovasc Genet 3: pp. 47-52. pdf

Constantineau, J., Greason, E., West, M., Filbin, M., Kieft, J.S., Carletti, M.Z., Christenson, L.K., Rodriguez, A. 2010. The synonymous variant in scavenger receptor, class B, type I gene is associated with lower SR-BI protein expression an function. Artherosclerosis 210: pp. 177-182. pdf

Pambianco, G., Lombardero, M., Bittner, V., Forker, A., Kennedy, F., Krishnaswami, A., Mooradian, A.D., Pop-Busui, R., Rana, J.S., Rodriguez, A., Steffes, M., Orchard, T.J. 2009. Control of lipids at baseline in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARD 2D) Trial. Prev Cardiol 12: pp. 9-18. pdf

Cherian-Shaw, M., Puttabyatappa, M., Greason, E., Rodriguez, A., Vandevoort, C.A.,Chaffin, C.L. 2009. Expression of scavenger receptor-BI and low density lipoprotein receptor and differential use of lipoproteins to support early steroidogenesis in luteinizing macaque granulosa cells. Endocrinology 150: pp. 957-965. pdf

West, M., Greason, E., Kolmakova, A., Jahangiri, A., Asztalos, B., Pollin, T.I., Rodriguez, A., 2009. Scavenger receptor class B type I protein as an independent predictor of high density lipoprotein cholesterol levels in subjects with  hyperalphalipoproteinemia. J Clin Endocrinol Metab 94: pp. 1451-1457. pdf

Roberts, C.G.P., Rodriguez, A. 2008. Authors' response to letter from strandberg and colleagues. J Gerontol A Bio Sci Med Sci.

Lipari, C.W., Garcia, J.E., Zhao, Y., Thrift, K., Vaidya, D., Rodriguez, A. 2008. Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation. Fertil Steril 28: pp. 1316-1318. pdf

Rodriguez, A., Muller, D.C., Metter, J., Harman, S.M., Blackman, M.R., Andres, R. 2007. Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab 92: pp. 3568-3572. pdf

Savransky, V., Nanayakkara, A., Li, J., Bevans, S., Smith, P.L., Rodriguez, A., Polotsky, V.Y. 2007. Chronic intermittent hypoxia induces atherosclerosis. American Journal of Respiutory and Critical Care Medicine 175: pp.1290-1297. pdf

Roberts, C.G.P., Shen, H., Mitchell, B.D., Damcott, C.M., Shuldiner, A., Rodriguez, A., 2007. Variants in scavenger receptor class B type I gene are associated with HDL cholesterol levels in younger women. Hum Hered 64: pp. 107-113. pdf

Roberts, C.G.P., Gualler, E., Rodriguez, A. 2007. Efficacy and safety of statin monotherapy on clinical outcomes in older adults: a meta-analysis. J Gerontology A Biol Sci Med 64: pp.107-113. pdf

Derr, R., Sivanandy, M., Bronich-Hall, Rodriguez, A. 2007. Insulin-related knowledge among health care professionals in internal medicine. Diabetes Spectrum 20: pp.879-887. pdf

A. Rodriguez-Oquendo. 2007.  Disorders of Lipid Metabolism.  In: Ambulatory Medicine, Fiebach, Kern, Thomas, and  Zieve, eds. Lippincott Williams and Wilkins, Philadelphia, PA. pp. 1395-1411.

A. Rodriguez-Oquendo and P.O. Kwiterovich, Jr. 2006.  Dyslipidemias.  In: Inborn Metabolic Diseases, Fernandes, Saudubray, van den Berghe, and Walter, eds. Springer Berlin Heidelberg Publishing Company, pp. 389-409.

Velasco, M., Alexander, C., King, J., Zhao, Y., Garcia, J., Rodriguez, A., 2006. Association of lower plasma estradiol levels and low expression of scavenger protein class B type I in infertile women. Fertil Steril 85: pp. 1391-1397. pdf

Li, J., Thorne, L.N., Punjab, N.M., Sun, C-K, Schwartz, A.R., Smith, P.L., Rodriguez, A., O'Donnell, C.P., Polotsky, V.Y. 2005. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 97: pp. 698-706. pdf

Desai, M.Y., Rodriguez, A., Wasserman, B.A., Gersenblith, G., Agarwal, S., Kennedy, M., Bluemke, D.A., Lima, J.A.C. 2005. Association of cholesterol subfractions and carotid lipid core measured by MRI. Arterioscler Thromb Vasc Biol 25: pp. e110-111. pdf

Rodriguez, A., Ashen, M.D., Chen, E.S., 2005. ACAT1 deletion in murine macrophages associated with cytotoxicity and decreased expression of collagen type 3A1. Biochem Biophys Res Commun 331: pp. 31-68. pdf

Rodriguez, A., Muller, D.C., Engelhardt, M., Andres, R. 2005. Contribution of impaired glucose tolerance in subjects with metabolic syndrome: Baltimore Longitudinal Study of Aging. Metabolism 54: pp. 542-547. pdf

Miller, M., Rhyne, J., Hamlette, S., Birnbaum, J., Rodriguez, A. 2003. Genetics of HDL regulation in humans. Current Opinion in Lipidology 14: pp. 273-279. pdf

Rodriguez, A., Doshi, R. 2003. Potential therapeutic agents that raise high-density lipoprotein cholesterol levels. Expert Opinion Therapeutic Patents 13: pp.167-175. pdf

Rodriguez, A., Usher, D.C. 2002. Anti-artherogenic effects of the acyl-CoA:cholesterol acyltransferase inhibitor, avasimide (CI-1011),  in cultured primary human macrophages. Atheroschlerosis 161: pp.45-54. pdf

Doshi, R., Wu, J., Fishelevich, R., Rodriguez, A. 2001.Update on the role of acyl-CoA:cholesterol acyltransferase inhibitors in atherosclerosis. Expert Opinion Therapeutic Patents 11: pp. 1655-1662. pdf

Wu, J., Doshi, R., Rodriguez, A. 2001. An update of the acyl-CoA:cholesterol inhibition in animal and human in vitro and in vivo models of atherosclerosis. Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents 1: pp. 41-150.

Rodriguez, A., Fishelevich, R. An ex-vivo study of foam cell formation and cholesterol clearance in macrophages isolated from patients with hypertriglyceridemia and low high-density lipoprotein cholesterol treated with high-dose Simvastatin. Heart Drug 1: pp. 32-34. pdf

A. Rodriguez-Oquendo and P.O. Kwiterovich, Jr. 2000.  Dyslipidemias.  In: Inborn Metabolic Diseases, Fernandes, Saudubray and  van den Berghe, eds. Springer Berlin Heidelberg Publishing Company, pp. 321-336.

Zanglungo, S., Amigo, L., Mendoza, H., Miguel, J.F., Vio, C., Glick, J., Rodriguez, A., Kozarsky, K., Quinones, V., Rigotti, A., Nervi, F. 2000.  Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice. Gastroenterology 119: pp.1708-1719. pdf