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UConn Health Department of Cell Biology

Mark Terasaki

Mark TerasakiAssociate Professor
Department of Cell Biology


Phone: 860-679-2695
Office: E6037

UConn Health
263 Farmington Avenue
Farmington, CT 06030

Research Interests

 Structure and function of the endoplasmic reticulum; serial section electron microscopy; plasma membrane re-sealing; mechanism of nuclear envelope breakdown.

Lab Member's page See posters of current work!

Selected Publications

Terasaki, M., Shemesh, T., Kasthuri, N., Klemm, R.W., Schalek, R., Hayworth, K.J., Hand, A.R., Yankova, M., Huber, G., Lichtman, J.W., Rapoport, T., and Kozlov, M.M. 2013. Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs. Cell 154: 285-296. pdf                                                                                                                See also Cell Preview: Marshall, W.F. 2013. Differential geometry meets the cell. Cell 154: 265-266. pdf

   This paper explains how parallel sheets of endoplasmic reticulum are connected. The existence of these sheet stacks and their function in synthesis of membrane and secreted proteins has been known for more than 60 years. Three-dimensional reconstructions from serial section electron micrographs from the mouse salivary gland show that the sheets are connected by twisted membrane surfaces with helical edges. The overall structure resembles a parking garage, in which the different levels are connected by helicoidal ramps. Theoretical calculations show that this structure minimizes the elastic energy of sheet edges and surfaces and allows dense packing of this organelle in the restricted space of a cell.

Green, S.A., Norris, R.P., Terasaki, M., Lowe, C.J. 2013. FGF signaling induces mesoderm in the hemichordate Saccoglossus kowalevskii. Development 140: 1024-1033. pdf

Darras, S., Gerhart, J., Terasaki, M., Kirschner, M., Lowe, C.J. 2011. B-Catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii. Development 138, 959-970. pdf

Terasaki, M., and Runft, L. 2010. Two-stage dependence for 1-methyladenine induced reinitiation of meiotic maturation in starfish oocytes. Exp. Cell Res. 316: 2654-2663. pdf

Lowe, C.J., Terasaki, M., Wu, M., Freeman, R., Runft, L., Kwan, K., Haigo, S., Aronowicz, J., Lander, E., Gruber, C., Kirschner, M., and Gerhart, J. 2006. Dorsoventral patterning in hemichordates: insights into early chordate evolution. PLOS 4: 1603-1619. pdf

Terasaki, M. 2006. Fluorescence quantitation in thick specimens, with an application to cyclin B-GFP expression in starfish oocytes. Biol. Cell 98: 245-252. pdf

Fein, A., and Terasaki, M. 2005. Rapid increase in plasma membrane chloride permeability during wound resealing in starfish oocytes. J. Gen. Physiol. 126: 151-159 pdf

Lenart, P., Daigle, N., Bacher, C., Hand, A.R. , Eils, R., Terasaki, M., and Ellenberg, J. 2005. A contractile nuclear actin network drives chromosome congression in oocytes. Nature 436: 812-818 pdf

Terasaki, M., Okumura, E., Hinkle, B., and Kishimoto, T. 2003. Localization and dynamics of Cdc2-cyclin B during meiotic reinitation in starfish oocytes. Mol. Biol. Cell 14:4685-4694. pdf

Slepchenko, B.M., and Terasaki, M. 2003. Cyclin aggregation and robustness of bio-switching. Mol. Biol. Cell 14: 4695-4706. pdf

Galbraith, J.A., and Terasaki, M. 2003. Controlled damage in thick specimens by multiphoton excitation. Mol. Biol. Cell 14: 1808-1817. pdf

Hinkle, B., Slepchenko, B., Rolls, M.M., Walther, T.C., Stein, P.A., Mehlmann, L.M., Ellenberg, J., and Terasaki, M. 2002. Chromosomal association of Ran during meiotic and mitotic divisions. J. Cell Sci. 115: 4685-4693. pdf

Terasaki, M., Runft, L., and Hand, A. 2001. Changes in organization of the endoplasmic reticulum during Xenopus oocyte maturation and egg activation. Mol. Biol. Cell 12: 1103-1116. pdf

Terasaki, M., Campagnola, P., Rolls, M.M., Stein, P., Ellenberg, J., Hinkle, B., and Slepchenko, B. 2001. A new model for nuclear envelope breakdown. Mol. Biol. Cell 12: 503-510. pdf